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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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Tricyclic antidepressants side effects

  • Post author:Ken Gillman
  • Post category:Antidepressants
  • Post published:1 March 2020
  • Post last modified:5 April 2025

The receptor affinities for H1, A1, Muscarinic (m1-6 subtypes) etc determine much of the profile of side effects.  This varies a lot between the various available TCAs (see detailed information…

Continue ReadingTricyclic antidepressants side effects

The TCAs Overview and Update

  • Post author:Sophie Duncan
  • Post category:Antidepressants/TCAs
  • Post published:6 April 2025
  • Post last modified:6 April 2025

AbstractThis commentary reviews the tricyclic antidepressants (TCAs) and their place in the treatment of depressive illness, updating information from my seminal review paper on their pharmacology (2007) with data from…

Continue ReadingThe TCAs Overview and Update

1. Reasons for choosing a TCA before an SSRI

  • Post author:Ken Gillman
  • Post category:General Pharmacology/SSRIs
  • Post published:12 January 2020
  • Post last modified:5 April 2025

These commentaries are based on Dr Gillman’s peer reviewed scientific papers, see Publications, 1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to…

Continue Reading1. Reasons for choosing a TCA before an SSRI

Clomipramine: Potent SNRI Anti-Depressant

  • Post author:Ken Gillman
  • Post category:Antidepressants/TCAs
  • Post published:11 October 2015
  • Post last modified:6 April 2025

AbstractThis commentary explains the pharmacology behind the evidence that clomipramine is the most potent and effective of the so-called SNRI antidepressant drugs, and probably the most potent non-MAOI antidepressant drug…

Continue ReadingClomipramine: Potent SNRI Anti-Depressant
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Recent Posts

  • Antidepressants – TCAs vs the rest
    13 November 2005/
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  • Tricyclic antidepressants side effects
    1 March 2020/
    0 Comments
  • [NEW] Important Announcement & Update
    6 July 2022/
    0 Comments
  • Taste, Wine, food, and combinations: Advances, and insights from science
    2 March 2020/
    0 Comments
  • Trump, psychopathy, and the Goldwater rule
    13 January 2021/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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