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Tricyclic antidepressants side effects

  • Post author:Dr Ken Gillman
  • Post category:Antidepressants/TCAs
  • Post published:March 1, 2020
  • Post last modified:June 18, 2022

The receptor affinities for H1, A1, Muscarinic (m1-6 subtypes) etc determine much of the profile of side effects.  This varies a lot between the various available TCAs (see detailed information…

Continue ReadingTricyclic antidepressants side effects

Reasons for choosing a TCA before an SSRI

  • Post author:Philip
  • Post category:General Pharmacology/SSRIs/TCAs
  • Post published:January 12, 2020
  • Post last modified:June 18, 2022

1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to an SSRI)2. Those whose current episode is severe or shows psychomotor retardation…

Continue ReadingReasons for choosing a TCA before an SSRI

Overview: MAOI and TCA interactions

  • Post author:Dr Ken Gillman
  • Post category:Antidepressants/MAOIs/TCAs
  • Post published:June 29, 2019
  • Post last modified:June 20, 2022

AbstractThis paper traces and analyses the historical origin of the mistakes and misconceptions surrounding the misinformation promulgated concerning the supposed interactions between MAOI and TCA drugs.  This is an object…

Continue ReadingOverview: MAOI and TCA interactions

Clomipramine: Potent SNRI Anti-Depressant

  • Post author:Dr Ken Gillman
  • Post category:Antidepressants/SNRIs/TCAs
  • Post published:October 11, 2015
  • Post last modified:June 18, 2022

Introduction: 50th birthday tributeClomipramine (CMI) is usually thought of by doctors as a treatment for obsessive-compulsive disorder (OCD). However, it is a potent antidepressant with dual SNRI action (see tables of comparative…

Continue ReadingClomipramine: Potent SNRI Anti-Depressant
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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