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Critical independent evaluations in psycho-pharmacology

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Tricyclic antidepressants side effects

  • Post author:Ken Gillman
  • Post category:Antidepressants/TCAs
  • Post published:1 March 2020
  • Post last modified:18 June 2022

The receptor affinities for H1, A1, Muscarinic (m1-6 subtypes) etc determine much of the profile of side effects.  This varies a lot between the various available TCAs (see detailed information…

Continue ReadingTricyclic antidepressants side effects

Reasons for choosing a TCA before an SSRI

  • Post author:Philip Dang
  • Post category:General Pharmacology/SSRIs/TCAs
  • Post published:12 January 2020
  • Post last modified:28 March 2023

1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to an SSRI)2. Those whose current episode is severe or shows psychomotor retardation…

Continue ReadingReasons for choosing a TCA before an SSRI

Overview: MAOI and TCA interactions

  • Post author:Ken Gillman
  • Post category:Antidepressants/MAOIs/TCAs
  • Post published:29 June 2019
  • Post last modified:14 January 2023

These commentaries are based on Dr Gillman’s peer reviewed scientific papers, see Publications, AbstractThis paper traces and analyses the historical origin of the mistakes and misconceptions surrounding the misinformation promulgated concerning…

Continue ReadingOverview: MAOI and TCA interactions

Clomipramine: Potent SNRI Anti-Depressant

  • Post author:Ken Gillman
  • Post category:Antidepressants/SNRIs/TCAs
  • Post published:11 October 2015
  • Post last modified:18 June 2022

Introduction: 50th birthday tributeClomipramine (CMI) is usually thought of by doctors as a treatment for obsessive-compulsive disorder (OCD). However, it is a potent antidepressant with dual SNRI action (see tables of comparative…

Continue ReadingClomipramine: Potent SNRI Anti-Depressant
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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