Reasons for choosing a TCA before an SSRI
1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to an SSRI)2. Those whose current episode is severe or shows psychomotor retardation…
1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to an SSRI)2. Those whose current episode is severe or shows psychomotor retardation…
Now that the SSRIs have been in use long enough to be seen in perspective it is clear they have side effect differences from the TCAs, with some advantages, albeit…
Sertraline is the logical first choice SSRI. I regard it as perceptibly superior to all the others.Sertraline probably has a significant activity for boosting dopamine, relatively somewhat stronger than venlafaxine’s…
MoclobemideSummaryTherapeutic doses of Moclobemide combined with any (S)SRI carries a significant risk of potentially fatal serotonin toxicity. This is especially so when multiple pharmaco-kinetic interactions via CYP-450 come into play.IntroductionMoclobemide…