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Dr Ken Gillman, MD

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Dopamine and Depression

  • Post author:Dr Ken Gillman
  • Post category:General Pharmacology
  • Post published:February 23, 2020
  • Post last modified:June 18, 2022

Introduction: Importance of Dopamine in DepressionReaders may appreciate that I have always thought and taught that the role of dopamine (DA) in depression has been neglected and under-appreciated.  There is…

Continue ReadingDopamine and Depression

The placebo response: Meaning or muddle? phenomenon or phantasm?

  • Post author:Philip
  • Post category:General Pharmacology
  • Post published:January 26, 2020
  • Post last modified:June 20, 2022

In brief This seems to be the latest in a persistently limp and desperate series of ‘new’ anti-depressants with ‘faster-better’ AD action. Evidence for any usefully novel action or efficacy…

Continue ReadingThe placebo response: Meaning or muddle? phenomenon or phantasm?

Reasons for choosing a TCA before an SSRI

  • Post author:Philip
  • Post category:General Pharmacology/SSRIs/TCAs
  • Post published:January 12, 2020
  • Post last modified:June 18, 2022

1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to an SSRI)2. Those whose current episode is severe or shows psychomotor retardation…

Continue ReadingReasons for choosing a TCA before an SSRI

Understanding Receptor Affinity Data

  • Post author:Dr Ken Gillman
  • Post category:General Pharmacology
  • Post published:November 13, 2010
  • Post last modified:June 18, 2022

It is common for medical researchers, medical professionals and people looking at data on the Internet, to misunderstand receptor affinity data, in relation to both its accuracy and its functional…

Continue ReadingUnderstanding Receptor Affinity Data

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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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