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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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Mirtazapine: dubious and misleading evidence

  • Post author:Ken Gillman
  • Post category:Antidepressants/Other
  • Post published:13 November 2014
  • Post last modified:18 June 2022

Mirtazapine is a topical example of a drug whose mechanism and potency of action may be elucidated by serotonin toxicity data. It is also an example of how drugs become…

Continue ReadingMirtazapine: dubious and misleading evidence

Depression: What Is It? Why Drug Treatment?

  • Post author:Ken Gillman
  • Post category:Antidepressants
  • Post published:13 November 2010
  • Post last modified:4 March 2023

A great deal has been written on the subject of defining the medical illness of depression. That is not a main theme of this website, nor do I profess to…

Continue ReadingDepression: What Is It? Why Drug Treatment?

Antidepressants – TCAs vs the rest

  • Post author:Ken Gillman
  • Post category:Antidepressants
  • Post published:13 November 2005
  • Post last modified:5 April 2025

The best tricyclic antidepressants remain important and effective treatments for major depressive disorder. However the relatively higher toxicity of some of them in overdose (especially dothiepin-- see ‘toxicity’), and other…

Continue ReadingAntidepressants – TCAs vs the rest

Antidepressants – Citalopram

  • Post author:Ken Gillman
  • Post category:Antidepressants/SSRIs
  • Post published:13 November 1999
  • Post last modified:18 June 2022

There is accumulating evidence that the SSRIs are less efficacious than TCAs and MAOIs for the treatment of major depression (see summary of Anderson's meta-analysis). This doubt seems to apply…

Continue ReadingAntidepressants – Citalopram
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Recent Posts

  • Antidepressants – TCAs vs the rest
    13 November 2005/
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  • Tricyclic antidepressants side effects
    1 March 2020/
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  • [NEW] Important Announcement & Update
    6 July 2022/
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  • Taste, Wine, food, and combinations: Advances, and insights from science
    2 March 2020/
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  • Trump, psychopathy, and the Goldwater rule
    13 January 2021/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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