Mirtazapine: dubious and misleading evidence
Mirtazapine is a topical example of a drug whose mechanism and potency of action may be elucidated by serotonin toxicity data. It is also an example of how drugs become…
Mirtazapine is a topical example of a drug whose mechanism and potency of action may be elucidated by serotonin toxicity data. It is also an example of how drugs become…
A great deal has been written on the subject of defining the medical illness of depression. That is not a main theme of this website, nor do I profess to…
The best tricyclic antidepressants remain important and effective treatments for major depressive disorder. However the relatively higher toxicity of some of them in overdose (especially dothiepin-- see ‘toxicity’), and other…
There is accumulating evidence that the SSRIs are less efficacious than TCAs and MAOIs for the treatment of major depression (see summary of Anderson's meta-analysis). This doubt seems to apply…