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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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The TCAs Overview and Update

  • Post author:Sophie Duncan
  • Post category:Antidepressants/TCAs
  • Post published: 6 April 2025
  • Post last modified: 2 October 2026

AbstractThis commentary reviews the tricyclic antidepressants (TCAs) and their place in the treatment of depressive illness, updating information from my seminal review paper on their pharmacology (2007) with data from…

Continue ReadingThe TCAs Overview and Update

1. Vortioxetine: Hope or Hype

  • Post author:Ken Gillman
  • Post category:Antidepressants/Newer ADs
  • Post published: 25 April 2021
  • Post last modified: 1 October 2026

In brief This seems to be the latest in a persistently limp and desperate series of ‘new’ anti-depressants with ‘faster-better’ AD action. Evidence for any usefully novel action or efficacy…

Continue Reading1. Vortioxetine: Hope or Hype

Reasons for choosing a TCA before an SSRI

  • Post author:Ken Gillman
  • Post category:General Pharmacology/SSRIs
  • Post published: 12 January 2020
  • Post last modified: 15 February 2026

1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to an SSRI)2. Those whose current episode is severe or shows psychomotor retardation…

Continue ReadingReasons for choosing a TCA before an SSRI

MAOI Update: Clarifications Concerning Pharmacology and Terminology

  • Post author:Ken Gillman
  • Post category:Antidepressants/MAOIs
  • Post published: 13 September 2019
  • Post last modified: 2 October 2026

AbstractThis paper points out that precise use of terms in pharmacology and nosology is essential to understanding MAOI drugs and their potential uses and interactions.  The approved indications for their…

Continue ReadingMAOI Update: Clarifications Concerning Pharmacology and Terminology
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Recent Posts

  • Pearl: Causal inference and the ‘do-operator’
    3 May 2026/
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  • Generalisability, external validity
    3 May 2026/
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  • The Credentials of Scientific Evidence Introduction
    3 May 2026/
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  • [NEW] Important Announcement & Update
    6 July 2022/
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  • Project: MAOIs, International Guidelines and WHO ‘Essential Medicines’ Listing
    17 March 2022/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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MAOIs: Introductory Comments
MAOI Diet Info Overview
Gillman’s Antidepressants Algorithm
Swapping From One MAOI To Another

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