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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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The TCAs Overview and Update

  • Post author:Sophie Duncan
  • Post category:Antidepressants/TCAs
  • Post published:6 April 2025
  • Post last modified:15 February 2026

AbstractThis commentary reviews the tricyclic antidepressants (TCAs) and their place in the treatment of depressive illness, updating information from my seminal review paper on their pharmacology (2007) with data from…

Continue ReadingThe TCAs Overview and Update

1. Vortioxetine: Hope or Hype

  • Post author:Ken Gillman
  • Post category:Antidepressants/Newer ADs
  • Post published:25 April 2021
  • Post last modified:26 November 2023

These commentaries are based on Dr Gillman’s peer reviewed scientific papers, see Publications, In brief This seems to be the latest in a persistently limp and desperate series of ‘new’ anti-depressants…

Continue Reading1. Vortioxetine: Hope or Hype

Reasons for choosing a TCA before an SSRI

  • Post author:Ken Gillman
  • Post category:General Pharmacology/SSRIs
  • Post published:12 January 2020
  • Post last modified:15 February 2026

1. Patients with previous episodes of severe depression (especially if it was unresponsive, or only partially responsive, to an SSRI)2. Those whose current episode is severe or shows psychomotor retardation…

Continue ReadingReasons for choosing a TCA before an SSRI

MAOI Update: Clarifications Concerning Pharmacology and Terminology

  • Post author:Ken Gillman
  • Post category:Antidepressants/MAOIs
  • Post published:13 September 2019
  • Post last modified:14 February 2026

AbstractThis paper points out that precise use of terms in pharmacology and nosology is essential to understanding MAOI drugs and their potential uses and interactions.  The approved indications for their…

Continue ReadingMAOI Update: Clarifications Concerning Pharmacology and Terminology
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Recent Posts

  • Generalisability, external validity
    3 May 2026/
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  • The Credentials of Scientific Evidence Introduction
    3 May 2026/
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  • Pearl: Casual inference and the ‘do-operator’
    3 May 2026/
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  • Lithium – Patient information
    14 November 1999/
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  • Lithium – Brief management protocol for doctors
    14 November 2003/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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MAOIs: Introductory Comments
MAOI Diet Info Overview
Gillman’s Antidepressants Algorithm
Swapping From One MAOI To Another

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