Dr Ken Gillman
Critical independent evaluations in psycho-pharmacology
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The tricyclic antidepressant (TCA) group of drugs have been in use for 70 years and are effective for severe and melancholic depression, often outperforming newer agents. They are also widely used for other disorders such as headache and pain.
These commentaries are based on Dr Gillman’s peer reviewed scientific papers, see Publications, Duloxetine does not have a ‘badge-engineered’ metabolite derivative to extend its patent, unlike Venlafaxine (Effexor, now out of…
Venlafaxine (Effexor, now out of patent) and its ‘badge-engineered’ metabolite off-spring (desvenlafaxine, Pristiq- in patent, which is even weaker than venlafaxine as an NRI) are examples of drugs whose attribution…
The receptor affinities for H1, A1, Muscarinic (m1-6 subtypes) etc determine much of the profile of side effects. This varies a lot between the various available TCAs (see detailed information…
PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.
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