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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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2. Bupropion: Still hazy

  • Post author:Ken Gillman
  • Post category:Antidepressants/Newer ADs
  • Post published: 26 September 2016
  • Post last modified: 1 October 2026

Bupropion: Still hazy after all these yearsIntroductionThis note on Bupropion BUP (Wellbutrin etc.) is an update about some new data that is helping to ‘lift the veil of ignorance’ a little further,…

Continue Reading2. Bupropion: Still hazy

Clomipramine: Potent SNRI Anti-Depressant

  • Post author:Ken Gillman
  • Post category:Antidepressants/TCAs
  • Post published: 11 October 2015
  • Post last modified: 2 October 2026

AbstractThis commentary explains the pharmacology behind the evidence that clomipramine is the most potent and effective of the so-called SNRI antidepressant drugs, and probably the most potent non-MAOI antidepressant drug…

Continue ReadingClomipramine: Potent SNRI Anti-Depressant

Understanding Receptor Affinity Data

  • Post author:Ken Gillman
  • Post category:General Pharmacology
  • Post published: 13 November 2010
  • Post last modified: 15 February 2026

It is common for medical researchers, medical professionals and people looking at data on the Internet, to misunderstand receptor affinity data, in relation to both its accuracy and its functional…

Continue ReadingUnderstanding Receptor Affinity Data

Homogeneity and Simpson’s paradox

  • Post author:Ken Gillman
  • Post category:RCTs and Pearl
  • Post published: 3 May 2026
  • Post last modified: 3 May 2026

The Credentials of Scientific Evidence: Rebalancing the Epistemological Scales  9.2.2 Homogeneity and Simpson’s paradox Abstract This commentary critiques the reliance on Randomized Controlled Trials (RCTs) in psychiatric research by examining…

Continue ReadingHomogeneity and Simpson’s paradox
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Recent Posts

  • Pearl: Causal inference and the ‘do-operator’
    3 May 2026/
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  • Generalisability, external validity
    3 May 2026/
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  • The Credentials of Scientific Evidence Introduction
    3 May 2026/
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  • [NEW] Important Announcement & Update
    6 July 2022/
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  • Project: MAOIs, International Guidelines and WHO ‘Essential Medicines’ Listing
    17 March 2022/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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