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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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Methylene Blue & Serotonin Toxicity Syndrome

  • Post author:Ken Gillman
  • Post category:Serotonin Toxicity
  • Post published: 14 November 2008
  • Post last modified: 2 October 2026

AbstractThis is the story of how an understanding of the spectrum concept of serotonin toxicity led to my hypothesis, then the experimental validation, of the potent MAO-A inhibitor potency of…

Continue ReadingMethylene Blue & Serotonin Toxicity Syndrome

The placebo response: Meaning or muddle? phenomenon or phantasm?

  • Post author:Ken Gillman
  • Post category:General Pharmacology
  • Post published: 26 January 2020
  • Post last modified: 1 October 2026

In briefThis seems to be the latest in a persistently limp and desperate series of ‘new’ anti-depressants with ‘faster-better’ AD action. Evidence for any usefully novel action or efficacy exists,…

Continue ReadingThe placebo response: Meaning or muddle? phenomenon or phantasm?

Stepped trials: Magnifying methodological muddles — the supernatant effect

  • Post author:Ken Gillman
  • Post category:Bias in Science
  • Post published: 12 June 2019
  • Post last modified: 15 February 2026

AbstractStepped trials such as STAR*D suffer from a serious methodological flaw.  In each stage of the trial one is dealing with a different population sample that has a different percentage…

Continue ReadingStepped trials: Magnifying methodological muddles — the supernatant effect

5. A professor’s illness

  • Post author:Ken Gillman
  • Post category:Patient Stories
  • Post published: 3 March 2018
  • Post last modified: 2 October 2026

View or download A Professor’s Illness PDFIntroductionStrongly anti-MAOI psychiatric professor suffers psychotic depression for years before being made well by TCPIn the introduction to the first patient story I commented…

Continue Reading5. A professor’s illness
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Recent Posts

  • Pearl: Causal inference and the ‘do-operator’
    3 May 2026/
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  • Generalisability, external validity
    3 May 2026/
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  • The Credentials of Scientific Evidence Introduction
    3 May 2026/
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  • [NEW] Important Announcement & Update
    6 July 2022/
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  • Project: MAOIs, International Guidelines and WHO ‘Essential Medicines’ Listing
    17 March 2022/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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