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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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2. Duloxetine: another SNRI myth

  • Post author:Ken Gillman
  • Post category:Antidepressants/SNRIs
  • Post published:29 March 2020
  • Post last modified:26 November 2023

These commentaries are based on Dr Gillman’s peer reviewed scientific papers, see Publications, Duloxetine does not have a ‘badge-engineered’ metabolite derivative to extend its patent, unlike Venlafaxine (Effexor, now out of…

Continue Reading2. Duloxetine: another SNRI myth

Tricyclic antidepressants side effects

  • Post author:Ken Gillman
  • Post category:Antidepressants
  • Post published:1 March 2020
  • Post last modified:5 April 2025

The receptor affinities for H1, A1, Muscarinic (m1-6 subtypes) etc determine much of the profile of side effects.  This varies a lot between the various available TCAs (see detailed information…

Continue ReadingTricyclic antidepressants side effects

The TCAs Overview and Update

  • Post author:Sophie Duncan
  • Post category:Antidepressants/TCAs
  • Post published:6 April 2025
  • Post last modified:6 April 2025

AbstractThis commentary reviews the tricyclic antidepressants (TCAs) and their place in the treatment of depressive illness, updating information from my seminal review paper on their pharmacology (2007) with data from…

Continue ReadingThe TCAs Overview and Update

Clomipramine: Potent SNRI Anti-Depressant

  • Post author:Ken Gillman
  • Post category:Antidepressants/TCAs
  • Post published:11 October 2015
  • Post last modified:6 April 2025

AbstractThis commentary explains the pharmacology behind the evidence that clomipramine is the most potent and effective of the so-called SNRI antidepressant drugs, and probably the most potent non-MAOI antidepressant drug…

Continue ReadingClomipramine: Potent SNRI Anti-Depressant
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Recent Posts

  • Lithium in the Environment, Diet and Body Pt 1
    14 November 2011/
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  • Lithium – Patient information
    14 November 1999/
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  • Lithium – Brief management protocol for doctors
    14 November 2003/
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  • Dietary Lithium: A critique of the claimed effect on depression and suicide
    23 February 2019/
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  • Lithium levels in tap-water & suicide
    12 August 2017/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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