Dr Ken Gillman, MD
Critical independent evaluations in psycho-pharmacology
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Duloxetine does not have a ‘badge-engineered’ metabolite derivative to extend its patent, unlike Venlafaxine (Effexor, now out of patent), and its patent-extending-metabolite, desvenlafaxine.This commentary will be short because it is…
The receptor affinities for H1, A1, Muscarinic (m1-6 subtypes) etc determine much of the profile of side effects. This varies a lot between the various available TCAs (see detailed information…
For the full text, please download the PDF using the button on the right. There are over 40 pages, 200 citations and almost 20,000 words. A table of contents is…
SummaryThere is an association of migraine with serious depression, encompassing the linked domains of genetics, patho-physiology and treatment response. A careful personal and family history of both disorders should be…
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