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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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Dopamine and Depression

  • Post author:Ken Gillman
  • Post category:General Pharmacology
  • Post published: 23 February 2020
  • Post last modified: 15 February 2026

Introduction: Importance of Dopamine in DepressionReaders may appreciate that I have always thought and taught that the role of dopamine (DA) in depression has been neglected and under-appreciated.  There is…

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The Risk of Harm From Acute Tyramine-induced Hypertension: How Significant?

  • Post author:Ken Gillman
  • Post category:Antidepressants/MAOIs
  • Post published: 17 May 2019
  • Post last modified: 2 October 2026

AbstractThere has been a long-standing presumption, ever since the original problems in the 1960s, that MAOIs produce a special risk of subarachnoid haemorrhage (SAH).  That was why MAOIs were briefly…

Continue ReadingThe Risk of Harm From Acute Tyramine-induced Hypertension: How Significant?

APA textbook update: MAOIs

  • Post author:Ken Gillman
  • Post category:Bias in Science
  • Post published: 10 October 2017
  • Post last modified: 15 February 2026

APA textbook — serious errorsIntroductionIn August of 2016, I posted some observations about serious errors in the APA textbook of psychopharmacology (4th ed.). I communicated my concerns to the editor, Dr…

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Gillman’s Antidepressants algorithm

  • Post author:Ken Gillman
  • Post category:Depressive Illness
  • Post published: 19 November 2016
  • Post last modified: 2 October 2026

Gillman’s Antidepressant algorithmSummaryThis commentary presents my antidepressant treatment algorithm which incorporates concepts from Bayesian reasoning and ‘critical path analysis’; that makes it a ‘multi-lane’ clinical pathway. It emphasises procedures which…

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Recent Posts

  • Pearl: Causal inference and the ‘do-operator’
    3 May 2026/
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  • Generalisability, external validity
    3 May 2026/
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  • The Credentials of Scientific Evidence Introduction
    3 May 2026/
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  • [NEW] Important Announcement & Update
    6 July 2022/
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  • Project: MAOIs, International Guidelines and WHO ‘Essential Medicines’ Listing
    17 March 2022/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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MAOIs: Introductory Comments
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