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Dr Ken Gillman

Critical independent evaluations in psycho-pharmacology

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The TCAs Overview and Update

  • Post author:Sophie Duncan
  • Post category:Antidepressants/TCAs
  • Post published:6 April 2025
  • Post last modified:15 February 2026

AbstractThis commentary reviews the tricyclic antidepressants (TCAs) and their place in the treatment of depressive illness, updating information from my seminal review paper on their pharmacology (2007) with data from…

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Clomipramine: Potent SNRI Anti-Depressant

  • Post author:Ken Gillman
  • Post category:Antidepressants/TCAs
  • Post published:11 October 2015
  • Post last modified:15 February 2026

AbstractThis commentary explains the pharmacology behind the evidence that clomipramine is the most potent and effective of the so-called SNRI antidepressant drugs, and probably the most potent non-MAOI antidepressant drug…

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Migraine & melancholic depression

  • Post author:Ken Gillman
  • Post category:Depressive Illness
  • Post published:20 November 2016
  • Post last modified:15 February 2026

SummaryThere is an association of migraine with serious depression, encompassing the linked domains of genetics, patho-physiology and treatment response. A careful personal and family history of both disorders should be…

Continue ReadingMigraine & melancholic depression

Recent Posts

  • Generalisability, external validity
    3 May 2026/
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  • The Credentials of Scientific Evidence Introduction
    3 May 2026/
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  • Pearl: Casual inference and the ‘do-operator’
    3 May 2026/
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  • Lithium – Patient information
    14 November 1999/
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  • Lithium – Brief management protocol for doctors
    14 November 2003/
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PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.

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MAOIs: Introductory Comments
MAOI Diet Info Overview
Gillman’s Antidepressants Algorithm
Swapping From One MAOI To Another

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