Mirtazapine is a topical example of a drug whose mechanism and potency of action may be elucidated by serotonin toxicity data. It is also an example of how drugs become…

This commentary is about the intra-neuronal storage of monoamines in vesicles.The vesicular monoamine transporter (VMAT2) is responsible for actively taking up all monoamines (i.e. dopamine (DA), serotonin (5-HT), norepinephrine (NE), epinephrine (EPI) and…

SummaryThis essay summarises the data and that indicates much of the early work published on mirtazapine was inaccurate and misleading, and points out that there is little evidence to substantiate…