Dr Ken Gillman
Critical independent evaluations in psycho-pharmacology
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The best tricyclic antidepressants remain important and effective treatments for major depressive disorder. However the relatively higher toxicity of some of them in overdose (especially dothiepin-- see ‘toxicity’), and other…
This is an updated summary of the advantages and potential disadvantages of combining stimulants such as amphetamine, methylphenidate, modafinil with MAOIs.
MoclobemideSummaryTherapeutic doses of Moclobemide combined with any (S)SRI carries a significant risk of potentially fatal serotonin toxicity. This is especially so when multiple pharmaco-kinetic interactions via CYP-450 come into play.IntroductionMoclobemide…
There is accumulating evidence that the SSRIs are less efficacious than TCAs and MAOIs for the treatment of major depression (see summary of Anderson's meta-analysis). This doubt seems to apply…
PsychoTropical is a knowledge and education resource started by Dr Gillman about 20 years ago. It is neither connected with, nor influenced by, any financial backing or interest group of any sort. The opinions expressed relate to Dr Gillman’s special knowledge and expertise as a recognised world-expert in MAOIs and serotonin toxicity.
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