PsychoTropicalResearch, serotonin and serotonin syndrome research.

Path to the current page: www.psychotropical.com>>Side_effects_Sedation.shtml

• Home

• Serotonin toxicity / Serotonin syndrome
  • Introduction
  • Summary
  • Spectrum Concept
  • Neuroleptic malignant syndrome
  • Moclobemide & (S)SRIs
  • The clinical picture
  • Treatment of ST
  • MOI-OA-ST
  • Mirtazapine
  • Methylene Blue

• Psychopharmacology Update Notes
  • Mirtazapine
  • Why most new antidepressants are ineffective
  • Dual action antidepressant drugs
  • Lamotrigine
  • Diet and Monoamine oxidase inhibitors
  • Monoamine oxidase inhibitors
  • Latest PUN Notes
  • Serotonin Notes

• Drug Interaction (CYP450) Information
  • Introduction
  • Overview
  • Quiz
  • Quiz Answers
  • CYP notes

• Psychopharmacology Questions Answered

• Publications

• Medico-legal opinions

• Patient Information

• Contact me
  • Contact Dr Gillman
  • Request serotonin toxicity document
  • Offer financial aid

---

Please help

Donate using PayPal

Side effects - Sedation

Date Created: 23/06/1999   Last Modified: 19/01/2002   Last Checked: 21/10/2002

For antidepressants and anti-psychotics (neuroleptics) this relates mainly to Histamine (H1) blockade potency (assuming the drug crosses the blood / brain barrier). See other notes for details of H1 affinities of various drugs.

In brief, from most to least sedative in rank order;

Neuroleptics

Very sedative:-- Clozapine, Chlorpromazine, Thioridazine

Much less:-- Thiothixene, Olanzapine, Fluphenazine

Non-sedative:-- Risperidone, Haloperidol

TCAs

V sedative:-- Mianserin, Doxepin, Amitriptyline, Dothiepin

Much less sedative:-- Nortriptyline, Clomipramine, Imipramine,

Non-sedative:-- Desipramine, lofepramine.

All text ©Dr Ken Gillman MRC Psych - PsychoTropical Research®


|Return to the menu at the top of this page|