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Neuroleptic Malignant Syndrome - Symptoms

Date Created: 10/05/1999   Last Modified: 11/10/1999   Last Checked: 10/07/2001

SS versus NMS
Feature SS / NMS
Serotonin syndrome
Serotomimetic drug +++/ 0
Rapid onset +++/ 0
Mental state changes--agitation +++/ akathisia
Mental state changes--confusion +/ ++
Mental state changes--hyperactivity +++/ 0
Clonus +++/ 0
Myoclonus +++/ 0
Ocular oscillations +++/ 0
Shivering +++/ 0
Tremor +++/ +
Hyperreflexia +++/ 0 Neuroleptic malignant syndrome
Neuroleptic 0/ ++
Slow onset 0/ ++
Bradykinesia/stupor 0/ +++
Leaden rigidity 0/ +++
Autonomic instability + / ++ Non-specific
Hyperpyrexia ++/ ++
Diaphoresis ++/ +++
Tachypnoea ++/ +++
Tachycardia ++/ +++
Hypertension ++/ ++
Confusion ++/ +++ c
Raised creatinine phosphokinase +/ +++

*** from Gillman PK 1998 (Fundamental & Clinical Pharmacology)

All text ©Dr Ken Gillman MRC Psych - PsychoTropical Research®


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