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Cytochrome P450 enzymes - Introduction
Cytochrome P450 enzymes - Quiz
An indicator of knowledge about cytochrome P450 enzymes (CYP450)
For each stem there are some alternatives that are probably accurate but only one that is almost certainly inaccurate.
The inaccurate options are listed separately. A simple score can be generated by allocating 1 for each incorrect statement identified.
Increased knowledge of the subject will enable a fuller explanation of why the other alternatives are probably accurate. That may be a more useful measure that individuals may use for themselves after looking at the information at www.psychotropical.com
Questions 1 through 4. Which one of the combinations of commonly used drugs below has not been documented to cause, or been implicated in causing, serious or fatal interactions (as a result of CYP450 interactions)
1)
codeine and paroxetine
beta-blockers and fluoxetine
dothiepin and paroxetine
2)
erythromycin and ergotamine
ketoconazole and sildenafil
nefazodone and lorazepam
3)
'statins and nefazodone
carbamazepine and clarithromycin
clomipramine and moclobemide
4)
Phenytoin and fluvoxamine
tolbutamide and citalopram
warfarin and fluoxetine
5) Which one of the widely used 'OTC' health remedies below does not appear to significantly block any CYP450 enzyme sub-type:--
Hypericum perforatum (St. John's wort)
Matricaria chamomilla (chamomile)
High dose vitamin E
Hydrastis canadensis (goldenseal)
6) CYP450 2D6 is not significantly blocked by which one of the following
paroxetine
nefazodone
fluoxetine
7) CYP450 3A4 is not significantly blocked by which one of the following
ketoconazole
quinidine
fluoxetine
8) CYP450 2C9 is not significantly blocked by which one of the following
fluvoxamine
fluoxetine
mirtazapine
All text ©Dr Ken Gillman MRC Psych - PsychoTropical Research®
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