PsychoTropicalResearch, serotonin and serotonin syndrome research.

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• Serotonin toxicity / Serotonin syndrome
  • Introduction
  • Summary
  • Spectrum Concept
  • Neuroleptic malignant syndrome
  • Moclobemide & (S)SRIs
  • The clinical picture
  • Treatment of ST
  • MOI-OA-ST
  • Mirtazapine
  • Methylene Blue

• Psychopharmacology Update Notes
  • Mirtazapine
  • Why most new antidepressants are ineffective
  • Dual action antidepressant drugs
  • Lamotrigine
  • Diet and Monoamine oxidase inhibitors
  • Monoamine oxidase inhibitors
  • Latest PUN Notes
  • Serotonin Notes

• Drug Interaction (CYP450) Information
  • Introduction
  • Overview
  • Quiz
  • Quiz Answers
  • CYP notes

• Psychopharmacology Questions Answered

• Publications

• Medico-legal opinions

• Patient Information

• Contact me
  • Contact Dr Gillman
  • Request serotonin toxicity document

Introduction

Welcome to my web site. I am Dr Ken Gillman, an internationally acknowledged authority on serotonin toxicity (ST), sometimes called serotonin syndrome (SS), and also an expert on other sorts of drug interactions, side effects and adverse effects. I live in tropical North Queensland, Australia: hence the name ‘psychotropical’; tropical and psychotropic (i.e. a drug that affects the brain). This web site provides freely accessible information and expert analysis about ST and psychopharmacology, divided into several sections:

1. Serotonin Toxicity / Serotonin Syndrome.
2. Psychotropic drugs in general (especially antidepressants, including monoamine oxidase inhibitors (MAOI)).
3. Drug-drug interaction information, in relation to CYP450 enzymes.

'Psychopharmacology Update Notes (PUN) and essays' has been going for 15 years, and has been on this web site for about 10 years. It has been developed as a free knowledge resource intended to be understandable and useful for both doctors and non-medical enquirees. It aims to balance the biased information from ‘commercial’ sources. It contains some information that might not otherwise be available. Most of these sources are dependent on the excessively prominent viewpoint that is manipulated and spread by pharmaceutical companies. See my theme essay, ‘Why Most New Antidepressants Are Ineffective: And How Pharmaceutical Companies Have Deceived Doctors ’, as well as other general essays and many short (PUN) notes. It is independent of pharmaceutical companies, is funded solely by me, and is my responsibility and opinion.

I retired from full time clinical work as a psychiatrist in 2006. I continue to do independent theoretical research and reviews relating to my interests in clinical neuropharmacology and psychopharmacology. I have published extensively over a period of 30 years (see 'Publications') and continue to do so.

I now offer expert medico-legal opinion and advice on serotonin toxicity (ST), serotonin syndrome (SS), neuroleptic malignant syndrome (NMS), drug-drug interactions, drug side effects and related topics (see Medico-legal opinions).

I will also answer more detailed inquiries about psychopharmacology and drug-drug interactions. See (Psychopharmacology Questions Answered).

The serotonin toxicity, serotonin syndrome information on this site is as comprehensive and up to date and accurate as any available anywhere. Many researchers in this field regard this site as the essential source of authoritative information.

Serotonin, Enteramine. IUPAC: 3-(2-aminoethyl)-1H-indol-5-ol

Molecular formula: C10H12N2O, molecular weight 176.215 g/mol).

See this link to PubChem compound (NLM) for a representation of the molecular structure:--

It is usually referred to as 5-hydroxytryptamine (5-HT). It was discovered in 1948, and by 1950 it was found to be involved in the actions of the two particularly significant drugs then available, reserpine and lysergic acid diethylamide (LSD). It thus played a significant role in the birth of the discipline now referred to as Psychopharmacology.

Please use the CONTACT ME button in the menu to get in touch.

All text ©Dr Ken Gillman MRC Psych - PsychoTropical Research®


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